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    It prevents the chemical norepinephrine, or adrenaline, from being released throughout the body.

    Each time, Blair felt exasperated: When necessary, authors of included articles were contacted in order to retrieve summary continuous data that were not provided in their trial report. None of them worked. Clinical evidence for the effects of propranolol in the treatment of anxiety disorders has never before been systematically reviewed.

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    Eligibility criteria Only placebo-controlled, comparative parallel group and crossover RCTs were eligible when they included human subjects with any of the anxiety disorders as included in the current version American Psychiatric Association, or previous versions of the Diagnostic and Statistical Manual DSM for an evaluation of the therapeutic effects of propranolol or .

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    There was no restriction on the basis of sample size, duration of follow-up, primary or secondary outcomes, duration or severity of symptoms, presence of comorbid disorders, or demographic variables of subjects.


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